Modulation of the tissue microenvironment to enhance the effects of cell transplantation paul s lee and terrence m yau effect of nanofibrous scaffolding on stem cell differentiation and tissue formation laura a smith and peter x ma tissue engineering and bioengineering of stem cells. The 3 major elements of tissue engineered constructs are the seeded cells the scaffolds and the microenvironment seeded cells are considered to be the main component for exerting biological functions over the last decade mesenchymal stem cells mscs have been intensively studied as an ideal cell source for tissue engineering applications. Stem cell bioengineering and tissue engineering microenvironment pp 287 313 2011 no access stem cell bioengineering and microencapsulation current perspective and future potentials arghya paul. Microengineering hydrogels for stem cell bioengineering and tissue regeneration our research group aims to develop and use technologies to recreate cell microenvironment interactions in order to produce in some of the initial studies in the use of microfabrication techniques for tissue engineering were done in attempts to engineer